Hydrochloric Acid → 5-Amino-1-methyl-1,2-dihydropyridin-2-one hydrochloride
Reaction equation
[CH3:1][N:2]1[C:7](=[O:8])[CH:6]=[CH:5][C:4]([NH:9]C(=O)OC(C)(C)C)=[CH:3]1.[ClH:17]>O1CCOCC1>[ClH:17].[NH2:9][C:4]1[CH:5]=[CH:6][C:7](=[O:8])[N:2]([CH3:1])[CH:3]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 70 °C
Procedure
To a stirred solution of tert-butyl 1-methyl-6-oxo-1,6-dihydropyridin-3-ylcarbamate (1.20 g, 5.35 mmol) in dioxane (15 mL) at RT was added HCl (4M in dioxane, 5.35 mL, 21.4 mmol). The reaction mixture was heated at 70° C. for 9 h, cooled to RT and filtered to give the title compound.
Workup
- temperaturecooled to RT
- filtrationfiltered
Sources & evidence
- ORD record
- ord-47c2908b888c4251ad74288607878f95
- Source dataset
- uspto-grants-2012_05
- Patent number
- US08178557B2
Reaction notes
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