2,4-Dichloropyrimidine → 2'-Chloro-6-trifluoromethyl-4-(4-trifluoromethyl-phenyl)-[2,4']bipyrimidinyl
Reaction equation
I[C:2]1[N:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][CH:13]=2)[N:3]=1.[Cl:22][C:23]1[N:28]=[C:27](Cl)[CH:26]=[CH:25][N:24]=1>>[Cl:22][C:23]1[N:28]=[C:27]([C:2]2[N:3]=[C:4]([C:12]3[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][CH:13]=3)[CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:7]=2)[CH:26]=[CH:25][N:24]=1Participants
3
Procedure
The title compound was prepared from 2-iodo-4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine (example A.4) (1.0 g, 2.39 mmol) and 2,4-dichloro-pyrimidine (0.356 g, 2.39 mmol) according to the general procedure IVc. Obtained as an off-white solid (0.49 g, 50%). MS (EI) 404.1 [(M)+]; mp 152° C.
Sources & evidence
- ORD record
- ord-0afa050f157b4b85a3ce33c4c1502bcf
- Source dataset
- uspto-grants-2012_05