Diazepam → 7-chloro-1-methyl-5-phenyl-2-trimethylsiloxy-1H-1,4-benzodiazepine

HRID 192901

Reaction equation

HRID 192901 reaction equation
[CH3:30][Si:31]([Cl:32])([CH3:33])[CH3:34].[CH3:35][CH2:36][O:37][CH2:38][CH3:39].[CH:3]([NH:4][CH:5]([CH3:6])[CH3:7])([CH3:8])[CH3:9].[Cl:10][c:11]1[cH:12][cH:13][c:14]2[c:15]([cH:29]1)[C:16]([c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1)=[N:17][CH2:18][C:19](=[O:22])[N:20]2[CH3:21].[Li:1][CH3:2].[O:40]1[CH2:41][CH2:42][CH2:43][CH2:44]1>>[Cl:10][c:11]1[cH:12][cH:13][c:14]2[c:15]([cH:29]1)[C:16]([c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1)=[N:17][CH:18]=[C:19]([O:22][Si:31]([CH3:30])([CH3:33])[CH3:34])[N:20]2[CH3:21]

Participants

7

Reactant 6

HCID 3016DiazepamHCID 3283Diethyl EtherHCID 6397ChlorotrimethylsilaneHCID 7912DiisopropylamineHCID 8028TetrahydrofuranHCID 178418348HCID 178418348, compound

Product 1

HCID 126021197-chloro-1-methyl-5-phenyl-2-trimethylsiloxy-1H-1,4-benzodiazepine

Sources & evidence

ORD record
ord-6bf9e727889849829e188b9bcc15f6cb
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Linked notes

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