Lithium hydroxide, monohydrate → 4-Chlorobiphenyl-2-carboxylic acid

Reaction equation

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[C:6]([CH:12]=1)[C:7]([O:9]CC)=[O:8].O.[OH-].[Li+]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)=[C:6]([CH:12]=1)[C:7]([OH:9])=[O:8]

Participants

Reactant 2

HCID 168937Lithium hydroxide, monohydrate

HCID 59830347Ethyl 5-chloro-2-phenylbenzoate

Product 1

HCID 219398584-Chlorobiphenyl-2-carboxylic acidYield 80%

Procedure

Ethyl 5-chloro-2-phenylbenzoate (0.473 g, 1.81 mmol) was hydrolyzed with lithium hydroxide monohydrate to provide 5-chloro-2-phenylbenzoic acid (0.336 g, 80% yield). MS (ESI) m/z: 233.0 (M+H+)

Sources & evidence

ORD record: ord-7b753704064341a18ea3d30fc7089020
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08188113B2

Reaction notes

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