tert-Butyl 4-oxopiperidine-1-carboxylate → tert-Butyl 3-(3-(3-fluorophenyl)propanoyl)-4-oxopiperidine-1-carboxylate

HRID 1930607

Reaction equation

HRID 1930607 reaction equation
[O:1]=[C:2]1[CH2:7][CH2:6][N:5]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH2:4][CH2:3]1.[F:15][C:16]1[CH:17]=[C:18]([CH2:22][CH2:23][C:24](Cl)=[O:25])[CH:19]=[CH:20][CH:21]=1>>[F:15][C:16]1[CH:17]=[C:18]([CH2:22][CH2:23][C:24]([CH:7]2[C:2](=[O:1])[CH2:3][CH2:4][N:5]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH2:6]2)=[O:25])[CH:19]=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 735900tert-Butyl 4-oxopiperidine-1-carboxylateHCID 189935013-(3-Fluorophenyl)propanoyl chloride

Product 1

HCID 59333733tert-Butyl 3-(3-(3-fluorophenyl)propanoyl)-4-oxopiperidine-1-carboxylateYield 48%

Procedure

tert-Butyl 3-(3-(3-fluorophenyl)propanoyl)-4-oxopiperidine-1-carboxylate (285 mg, 48%) was synthesised from tert-butyl 4-oxopiperidine-1-carboxylate and 3-(3-fluorophenyl)propanoyl chloride according to the general procedure for the preparation of diketones. MS (ES+) m/z 250 (M+H)+

Sources & evidence

ORD record
ord-41125c7fb85541a8968bc3f605dc388a
Source dataset
uspto-grants-2012_05
Patent number
US08188101B2

Linked notes

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