Trifluoroacetic acid → 3-(Trifluoromethyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine

Reaction equation

[F:1][C:2]([F:32])([F:31])[C:3]1[CH:4]=[C:5]2[CH2:11][N:10](C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[CH2:9][C:6]2=[N:7][CH:8]=1.FC(F)(F)C(O)=O>>[F:32][C:2]([F:1])([F:31])[C:3]1[CH:4]=[C:5]2[CH2:11][NH:10][CH2:9][C:6]2=[N:7][CH:8]=1

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 57753550HCID 57753550, compound

Product 1

HCID 532498903-(Trifluoromethyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine

Procedure

Prepared in analogy to Example A2 (c) from 3-Trifluoromethyl-6-trityl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine and trifluoroacetic acid. Yellow oil. MS (m/e): 189.4 ([M+H+, 100%).

Sources & evidence

ORD record: ord-2589b9be56c34ed1b9d4fae1dd304760
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08188139B2

Reaction notes

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