Hydrochloric Acid → 5-(2-Methyl-pyridin-4-yl)-2,3-dihydro-1H-isoindole

HRID 1930837Notes

Reaction equation

HRID 1930837 reaction equation
C(OC([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([C:17]3[CH:22]=[CH:21][N:20]=[C:19]([CH3:23])[CH:18]=3)[CH:14]=2)[CH2:9]1)=O)(C)(C)C.Cl>>[CH3:23][C:19]1[CH:18]=[C:17]([C:13]2[CH:14]=[C:15]3[C:10](=[CH:11][CH:12]=2)[CH2:9][NH:8][CH2:16]3)[CH:22]=[CH:21][N:20]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 577532995-(2-Methyl-pyridin-4-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester

Product 1

HCID 577533135-(2-Methyl-pyridin-4-yl)-2,3-dihydro-1H-isoindole

Procedure

Prepared in analogy to Example A3(e) from 5-(2-Methyl-pyridin-4-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester and using trifluoacetic acid instead of hydrochloride acid. Brown solid. MS (m/e): 211.0 ([M+H]+, 100%)

Sources & evidence

ORD record
ord-1e6acb4c083f4811b91ebab12fb7cf43
Source dataset
uspto-grants-2012_05
Patent number
US08188139B2

Reaction notes

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