2-Aminothiazole → 2-[6-(2-Fluoro-phenyl)-pyridin-3-yloxy]-N-(thiazol-2-yl)-acetamide trifluoroacetic acid salt
Reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[F:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]1[N:20]=[CH:19][C:18]([O:21][CH2:22][C:23]([OH:25])=O)=[CH:17][CH:16]=1.[NH2:26][C:27]1[S:28][CH:29]=[CH:30][N:31]=1>>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[F:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]1[N:20]=[CH:19][C:18]([O:21][CH2:22][C:23]([NH:26][C:27]2[S:28][CH:29]=[CH:30][N:31]=2)=[O:25])=[CH:17][CH:16]=1Participants
3
Procedure
The title compound was prepared analogously as described in Example 30(d) from 90 mg (0.25 mmol) of [6-(2-fluoro-phenyl)-pyridin-3-yloxy]-acetic acid trifluoroacetic acid salt and 29.9 mg (0.3 mmol) of 2-aminothiazole. Yield: 16 mg.
Sources & evidence
- ORD record
- ord-1f8f4d2473e544d8a54c29416b87f7e8
- Source dataset
- uspto-grants-2012_05
- DOI