Tetrahydrofuran → 1-(6-Methoxypyridin-3-yl)-4-(trifluoromethyl)cyclohexanol

HRID 193154

Reaction equation

HRID 193154 reaction equation
[Br:6][c:7]1[cH:8][cH:9][c:10]([O:13][CH3:14])[n:11][cH:12]1.[CH2:1]([Li:2])[CH2:3][CH2:4][CH3:5].[CH2:26]1[O:27][CH2:28][CH2:29][CH2:30]1.[F:15][C:16]([CH:17]1[CH2:18][CH2:19][C:20](=[O:23])[CH2:21][CH2:22]1)([F:24])[F:25]>>[c:7]1([C:20]2([OH:23])[CH2:19][CH2:18][CH:17]([C:16]([F:15])([F:24])[F:25])[CH2:22][CH2:21]2)[cH:8][cH:9][c:10]([O:13][CH3:14])[n:11][cH:12]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 27348955-Bromo-2-methoxypyridineHCID 27774914-(Trifluoromethyl)cyclohexanoneHCID 178418339Butyllithium

Product 1

HCID 673350851-(6-Methoxypyridin-3-yl)-4-(trifluoromethyl)cyclohexanol

Sources & evidence

ORD record
ord-3f4ff06620784b2da5633fb03eda3a9c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Linked notes

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