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6-Bromoindole → HCID 178505392, compound

HRID 1938006
Notes
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Reaction equation

HRID 1938006 reaction equation
Brc1ccc2cc[nH]c2c1.CC1(C)OB(c2ccnc(N3CCOCC3)c2F)OC1(C)C>COCCOC.O.O=C([O-])[O-].[CH]1[CH][CH]C(P(c2ccccc2)c2ccccc2)[CH]1.[CH]1[CH][CH]C(P(c2ccccc2)c2ccccc2)[CH]1.[Cl][Pd][Cl].[Fe].[Na+].[Na+]>Fc1c(-c2ccc3cc[nH]c3c2)ccnc1N1CCOCC1
ParticipantsConditionsWorkupSources & evidenceReaction notes

Participants

8

Reactant 2

HCID 6764936-BromoindoleHCID 164142374-(3-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)pyridin-2-YL)morpholine

Product 1

HCID 178505392HCID 178505392, compoundYield 80%

Reagents, catalysts & solvents 5

HCID 10340Sodium CarbonateReagentHCID 178477754HCID 178477754, compoundCatalystHCID 962WaterSolventHCID 80711,2-DimethoxyethaneSolvent2×HCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenylInternal standard

Conditions

Temperature
85 °C

Workup

  1. stirringNo procedure recorded

Sources & evidence

ORD record
ord-8b39c1abce8546248c07f20dace90017
Source dataset
Pd_CN_Coupling_Informer_Library
DOI
10.1039/c5sc04751j
Original link
View source

Reaction notes

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On this pageParticipantsConditionsWorkupSources & evidenceReaction notes