1-Methylpyrrolidine-2-carboxylic acid → N-[2-[4-(4-cyano-1-methylimidazo[4,5-c]pyridin-6-yl)-2-(trifluoromethyl)phenoxy]ethyl]-N-ethyl-1-methylpyrrolidine-2-carboxamide

HRID 194033

Reaction equation

HRID 194033 reaction equation
[CH3:1][N:2]1[CH:3]([C:7](=[O:8])[OH:9])[CH2:4][CH2:5][CH2:6]1.[CH3:43][n:44]1[cH:45][n:46][c:47]2[c:48]([C:69]#[N:70])[n:49][c:50](-[c:53]3[cH:54][c:55]([C:65]([F:66])([F:67])[F:68])[c:56]([O:59][CH2:60][CH2:61][NH:62][CH2:63][CH3:64])[cH:57][cH:58]3)[cH:51][c:52]12.[CH:10]([N:11]([CH2:12][CH3:13])[CH:14]([CH3:15])[CH3:16])([CH3:17])[CH3:18].[Cl:71][CH2:72][Cl:73].[P-:19]([F:20])([F:21])([F:22])([F:23])([F:24])[F:25].[n:26]1([O:27][C:28]([N:29]([CH3:30])[CH3:31])=[N+:32]([CH3:33])[CH3:34])[c:35]2[cH:36][cH:37][cH:38][cH:39][c:40]2[n:41][n:42]1>>[CH3:1][N:2]1[CH:3]([C:7](=[O:9])[N:62]([CH2:61][CH2:60][O:59][c:56]2[c:55]([C:65]([F:66])([F:67])[F:68])[cH:54][c:53](-[c:50]3[n:49][c:48]([C:69]#[N:70])[c:47]4[n:46][cH:45][n:44]([CH3:43])[c:52]4[cH:51]3)[cH:58][cH:57]2)[CH2:63][CH3:64])[CH2:4][CH2:5][CH2:6]1

Participants

7

Reactant 6

HCID 5571-Methylpyrrolidine-2-carboxylic acidHCID 6344DichloromethaneHCID 9886HexafluorophosphateHCID 81531DiisopropylethylamineHCID 130500O-benzotriazol-1-yl-tetramethyluroniumHCID 594106421-methyl-6-(4-(2-(ethylamino)ethoxy)-3-(trifluoromethyl)phenyl)-1H-imidazo[4,5-c]pyridine-4-carbonitrile

Product 1

HCID 67388236N-[2-[4-(4-cyano-1-methylimidazo[4,5-c]pyridin-6-yl)-2-(trifluoromethyl)phenoxy]ethyl]-N-ethyl-1-methylpyrrolidine-2-carboxamide

Sources & evidence

ORD record
ord-8a37983a681e402bb4eaad3eb525ba3c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Linked notes

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