Dichloromethane → 4-(2-Methylindol-5-yloxy)-7-(3-(pyrrolidin-yl)propoxy)quinazoline

HRID 194120

Reaction equation

HRID 194120 reaction equation
[CH2:65]([Cl:66])[Cl:67].[N:56]1([CH2:61][CH2:62][CH2:63][OH:64])[CH2:57][CH2:58][CH2:59][CH2:60]1.[O:1]=[C:2]([O:3][CH:4]([CH3:5])[CH3:6])[N:7]=[N:8][C:9]([O:10][CH:11]([CH3:12])[CH3:13])=[O:14].[OH:15][c:16]1[cH:17][cH:18][c:19]2[c:20]([O:26][c:27]3[cH:28][c:29]4[cH:30][c:31]([CH3:36])[nH:32][c:33]4[cH:34][cH:35]3)[n:21][cH:22][n:23][c:24]2[cH:25]1.[c:37]1([P:38]([c:39]2[cH:40][cH:41][cH:42][cH:43][cH:44]2)[c:45]2[cH:46][cH:47][cH:48][cH:49][cH:50]2)[cH:51][cH:52][cH:53][cH:54][cH:55]1>>[O:15]([c:16]1[cH:17][cH:18][c:19]2[c:20]([O:26][c:27]3[cH:28][c:29]4[cH:30][c:31]([CH3:36])[nH:32][c:33]4[cH:34][cH:35]3)[n:21][cH:22][n:23][c:24]2[cH:25]1)[CH2:63][CH2:62][CH2:61][N:56]1[CH2:57][CH2:58][CH2:59][CH2:60]1

Participants

6

Reactant 5

HCID 6344DichloromethaneHCID 11776TriphenylphosphineHCID 75555Diisopropyl diazene-1,2-dicarboxylateHCID 2093421-PyrrolidinepropanolHCID 1357631147-Hydroxy-4-(2-methylindol-5-yloxy)quinazoline

Product 1

HCID 220308234-(2-Methylindol-5-yloxy)-7-(3-(pyrrolidin-yl)propoxy)quinazoline

Sources & evidence

ORD record
ord-2f91f5bbe8b249a6bab67f9f707fead7
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Linked notes

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