Benzoyl chloride → Benzamide, N-(4-hydroxybutyl)-
Reaction equation
[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:10][CH2:11][CH2:12][CH2:13][CH2:14][OH:15].C(N(CC)CC)C.C(=O)([O-])[O-].[Na+].[Na+]>ClCCl>[OH:15][CH2:14][CH2:13][CH2:12][CH2:11][NH:10][C:1](=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 1.16 mL (10 mmol) of benzoylchloride in 10 mL dichloromethane is added to 0.93 mL (10 mmol) of 4-amino-butan-1-ol and 4.2 mL (30 mmol) of triethylamine dissolved in 50 mL of dichloromethane. The mixture is stirred overnight. 50 mL of saturated sodium carbonate solution is added. The organic phase is separated, dried with sodium sulfate and the solvent evaporated.
Workup
- customThe organic phase is separated
- dry with materialdried with sodium sulfate
- customthe solvent evaporated
Sources & evidence
- ORD record
- ord-d7cddf9df1b04cc0ae01a38c48c794fa
- Source dataset
- uspto-grants-2013_03
- Patent number
- US08389555B2
Reaction notes
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