2-(Ethoxymethylene)propanedinitrile → 3,7-dip-tolyl-3H-imidazo[4,5-b]pyridine
Reaction equation
[C:1]1([CH3:22])[CH:6]=[CH:5][C:4]([NH:7][C:8]2[C:13]([NH2:14])=[C:12]([C:15]3[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][CH:16]=3)[CH:11]=[CH:10][N:9]=2)=[CH:3][CH:2]=1.[CH2:23](OC=C(C#N)C#N)C>C(O)(C)C>[C:1]1([CH3:22])[CH:2]=[CH:3][C:4]([N:7]2[C:8]3=[N:9][CH:10]=[CH:11][C:12]([C:15]4[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][CH:16]=4)=[C:13]3[N:14]=[CH:23]2)=[CH:5][CH:6]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
0.70 mol of N2,4-dip-tolylpyridine-2,3-diamine and 2.56 mol of 2-(ethoxymethylene)malonnitrile were added in 10 ml of isopropanol, and refluxed for 6 hours. The solution was removed and was purified by using column chromatography to thereby produce a solid crystalline product at a yield of 84%.