Dichloromethane → 3-Cyano-N-{4-[4-(3-pyrrolidin-1-yl-propoxy)-phenyl]-tetrahydro-pyran-4-ylmethyl}-benzenesulfonamide

HRID 194652

Reaction equation

HRID 194652 reaction equation
[C:31](#[N:32])[c:33]1[cH:34][c:35]([S:39](=[O:40])(=[O:41])[Cl:42])[cH:36][cH:37][cH:38]1.[CH3:24][CH2:25][N:26]([CH2:27][CH3:28])[CH2:29][CH3:30].[Cl:43][CH2:44][Cl:45].[N:1]1([CH2:6][CH2:7][CH2:8][O:9][c:10]2[cH:11][cH:12][c:13]([C:16]3([CH2:22][NH2:23])[CH2:17][CH2:18][O:19][CH2:20][CH2:21]3)[cH:14][cH:15]2)[CH2:2][CH2:3][CH2:4][CH2:5]1>>[N:1]1([CH2:6][CH2:7][CH2:8][O:9][c:10]2[cH:11][cH:12][c:13]([C:16]3([CH2:22][NH:23][S:39]([c:35]4[cH:34][c:33]([C:31]#[N:32])[cH:38][cH:37][cH:36]4)(=[O:40])=[O:41])[CH2:17][CH2:18][O:19][CH2:20][CH2:21]3)[cH:14][cH:15]2)[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 28013603-Cyanobenzene-1-sulfonyl chlorideHCID 11645410(4-[4-(3-Pyrrolidin-1-ylpropoxy)phenyl]tetrahydropyran-4-yl}methylamine

Product 1

HCID 598374733-Cyano-N-{4-[4-(3-pyrrolidin-1-yl-propoxy)-phenyl]-tetrahydro-pyran-4-ylmethyl}-benzenesulfonamide

Sources & evidence

ORD record
ord-74bc13f41c7e4ef7bd6652b1628e78b0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Linked notes

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