1-Amino-4-naphthol → 6-(cyclohexylamino)-N-(4-hydroxy-1-naphthyl)pyrimidine-4-carboxamide

HRID 1946708

Reaction equation

HRID 1946708 reaction equation
[CH:1]1([NH:7][C:8]2[N:13]=[CH:12][N:11]=[C:10]([C:14]([OH:16])=O)[CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:17][C:18]1[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[C:21]([OH:28])=[CH:20][CH:19]=1>>[CH:1]1([NH:7][C:8]2[N:13]=[CH:12][N:11]=[C:10]([C:14]([NH:17][C:18]3[C:27]4[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=4)[C:21]([OH:28])=[CH:20][CH:19]=3)=[O:16])[CH:9]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 178151-Amino-4-naphtholHCID 594470756-(Cyclohexylamino)pyrimidine-4-carboxylic acid2×

Product 1

HCID 251826256-(cyclohexylamino)-N-(4-hydroxy-1-naphthyl)pyrimidine-4-carboxamide

Procedure

Following the general method as outlined in Example 1, starting from 6-(cyclohexylamino)pyrimidine-4-carboxylic acid (Intermediate 4) and 4-amino-1-naphtol (Aldrich), the title compound was obtained as a grey solid.

Sources & evidence

ORD record
ord-7ee0b5f55cc04565ac2444f48501834b
Source dataset
uspto-grants-2013_03
Patent number
US08399448B2

Linked notes

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