Water → 8-(2-Pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-[1,6]naphthyridine

HRID 194680

Reaction equation

HRID 194680 reaction equation
[Br:1][c:2]1[cH:3][n:4][cH:5][c:6]2[cH:7][cH:8][cH:9][n:10][c:11]12.[O:29]=[CH:30][N:31]([CH3:32])[CH3:33].[OH2:34].[cH:35]1[cH:36][cH:37][c:38]([P:39]([Pd:40]([P:41]([c:42]2[cH:43][cH:44][cH:45][cH:46][cH:47]2)([c:48]2[cH:49][cH:50][cH:51][cH:52][cH:53]2)[c:54]2[cH:55][cH:56][cH:57][cH:58][cH:59]2)([P:60]([c:61]2[cH:62][cH:63][cH:64][cH:65][cH:66]2)([c:67]2[cH:68][cH:69][cH:70][cH:71][cH:72]2)[c:73]2[cH:74][cH:75][cH:76][cH:77][cH:78]2)[P:79]([c:80]2[cH:81][cH:82][cH:83][cH:84][cH:85]2)([c:86]2[cH:87][cH:88][cH:89][cH:90][cH:91]2)[c:92]2[cH:93][cH:94][cH:95][cH:96][cH:97]2)([c:98]2[cH:99][cH:100][cH:101][cH:102][cH:103]2)[c:104]2[cH:105][cH:106][cH:107][cH:108][cH:109]2)[cH:110][cH:111]1.[n:12]1[c:13](-[c:18]2[c:19]([B:26]([OH:27])[OH:28])[c:20]3[n:21]([n:22]2)[CH2:23][CH2:24][CH2:25]3)[cH:14][cH:15][cH:16][cH:17]1>>[c:2]1(-[c:19]2[c:18](-[c:13]3[n:12][cH:17][cH:16][cH:15][cH:14]3)[n:22][n:21]3[c:20]2[CH2:25][CH2:24][CH2:23]3)[cH:3][n:4][cH:5][c:6]2[cH:7][cH:8][cH:9][n:10][c:11]12

Participants

6

Reactant 5

HCID 962WaterHCID 6228DimethylformamideHCID 8172708-Bromo-1,6-naphthyridineHCID 59710031(2-pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-3-boronic acidHCID 178420554HCID 178420554, compound

Product 1

HCID 586119458-(2-Pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-[1,6]naphthyridine

Sources & evidence

ORD record
ord-2722800fa861498999d4574844434b98
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Linked notes

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