Hydrochloric Acid → HCID 178446226, compound

HRID 1947258

Reaction equation

HRID 1947258 reaction equation
[CH:1]1([NH:7][C:8]2[C:12]3([CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]3)[N:11]([CH2:25][CH2:26][CH2:27][CH:28]=[CH2:29])[C:10](=[O:30])[N:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:31]>C(Cl)Cl>[ClH:31].[ClH:31].[CH:1]1([NH:7][C:8]2[C:12]3([CH2:13][CH2:14][NH:15][CH2:16][CH2:17]3)[N:11]([CH2:25][CH2:26][CH2:27][CH:28]=[CH2:29])[C:10](=[O:30])[N:9]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178446227HCID 178446227, compound

Product 1

HCID 178446226HCID 178446226, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of tert-butyl 4-(cyclohexylamino)-2-oxo-1-pent-4-en-1-yl-1,3,8-triazaspiro[4.5]dec-3-ene-8-carboxylate (785 mg, 1.88 mmol) in DCM (2 mL) was added HCl (1.64 mL, 6.56 mmol, 4N dioxane). The reaction mixture was stirred at rt for 1 h, concentrated in vacuo, taken in DCM and concentrated in vacuo again, to provide the desired product LRMS (M+1)=319.

Workup

  1. concentrationconcentrated in vacuo
  2. concentrationconcentrated in vacuo again

Sources & evidence

ORD record
ord-5b000049571d46719e27c2eccf9bbefb
Source dataset
uspto-grants-2013_03
Patent number
US08399473B2

Linked notes

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