Tetrahydrofuran → (2-Fluoro-4-methoxyphenyl)(6-methoxy-2-naphthyl)methanol

HRID 194913

Reaction equation

HRID 194913 reaction equation
[Br:6][c:7]1[cH:8][c:9]2[cH:10][cH:11][c:12]([O:17][CH3:18])[cH:13][c:14]2[cH:15][cH:16]1.[CH2:1]([Li:2])[CH2:3][CH2:4][CH3:5].[CH2:30]1[O:31][CH2:32][CH2:33][CH2:34]1.[F:19][c:20]1[c:21]([CH:22]=[O:23])[cH:24][cH:25][c:26]([O:28][CH3:29])[cH:27]1>>[c:7]1([CH:22]([c:21]2[c:20]([F:19])[cH:27][c:26]([O:28][CH3:29])[cH:25][cH:24]2)[OH:23])[cH:8][c:9]2[cH:10][cH:11][c:12]([O:17][CH3:18])[cH:13][c:14]2[cH:15][cH:16]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 787862-Bromo-6-methoxynaphthaleneHCID 27348732-Fluoro-4-methoxybenzaldehydeHCID 178418339Butyllithium

Product 1

HCID 22285701(2-Fluoro-4-methoxyphenyl)(6-methoxy-2-naphthyl)methanol

Sources & evidence

ORD record
ord-e0f91463a0d4402fb0656024a0dc5f99
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Linked notes

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