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Isopropylamine → HCID 67153316, compound

HRID 1949316
Notes
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Reaction equation

HRID 1949316 reaction equation
CS(O[CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([C:15]2[N:19]([C:20]3[CH:25]=[CH:24][CH:23]=[C:22]([Cl:26])[CH:21]=3)[N:18]=[C:17]([C:27]([N:29]3[CH2:33][C:32](=[O:34])[NH:31][CH2:30]3)=[O:28])[CH:16]=2)[CH:10]=1)(=O)=O.[CH:35]([NH2:38])([CH3:37])[CH3:36].[CH:39]([OH:41])=[O:40].ClC1C=C(N2C(C3C=CC=C(OCCCN(C)C)C=3)=CC(C(N3CC(=O)NC3)=O)=N2)C=CC=1>O1CCCC1>[CH:39]([OH:41])=[O:40].[Cl:26][C:22]1[CH:21]=[C:20]([N:19]2[C:15]([C:11]3[CH:12]=[CH:13][CH:14]=[C:9]([O:8][CH2:7][CH2:6][NH:38][CH:35]([CH3:37])[CH3:36])[CH:10]=3)=[CH:16][C:17]([C:27]([N:29]3[CH2:33][C:32](=[O:34])[NH:31][CH2:30]3)=[O:28])=[N:18]2)[CH:25]=[CH:24][CH:23]=1
ParticipantsProcedureSources & evidenceReaction notes

Participants

5

Reactant 3

HCID 6363IsopropylamineHCID 58277451HCID 58277451, compoundHCID 67153505HCID 67153505, compound

Product 1

HCID 67153316HCID 67153316, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The preparation of the title compound takes place starting from the compound of Example 121A and isopropylamine without the addition of tetrahydrofuran in analogy to the synthesis of the compound of Example 29. 29 mg (28% of theory) of the title compound are obtained.

Sources & evidence

ORD record
ord-5f2fcc30825e4a8e84b22cf986aad3c0
Source dataset
uspto-grants-2013_03
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US08399682B2

Reaction notes

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On this pageParticipantsProcedureSources & evidenceReaction notes