2,5-Dihydrofuran → HCID 68158227, compound

Reaction equation

[CH3:1][O:2][CH:3]([O:8][CH3:9])[CH2:4][N+:5]([O-:7])=O.[O:10]1[CH2:14][CH:13]=[CH:12][CH2:11]1>>[CH3:9][O:8][CH:3]([O:2][CH3:1])[C:4]1[C@H:12]2[CH2:11][O:10][CH2:14][C@H:13]2[O:7][N:5]=1

Participants

Reactant 2

HCID 155702,5-Dihydrofuran

HCID 114577221,1-Dimethoxy-2-nitroethane

Product 1

HCID 68158227HCID 68158227, compound

Procedure

Starting from the commercially available 1,1-dimethoxy-2-nitroethane (CAS69425-53-2) and 2,5-dihydro-furan following general procedure A, the product (3aS,6aS)-rel-3-dimethoxymethyl-3a,4,6,6a-tetrahydro-furo[3,4-d]isoxazole was obtained as a light brown oil.

Sources & evidence

ORD record: ord-33ec418922124d07b2a8d3044191493d
Source dataset: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08404680B2

Reaction notes

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