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Hydrochloric Acid → HCID 66985215, compound

HRID 1950779
Notes
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Reaction equation

HRID 1950779 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:11][C:12]2[C:13]3[C:23](=[O:24])[NH:22][CH:21]=[CH:20][C:14]=3[N:15]=[C:16](SC)[N:17]=2)[CH:6]=[C:7]([O:9][CH3:10])[CH:8]=1.C([NH:32][CH:33]1[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]1)(OC(C)(C)C)=O.[ClH:39]>O1CCOCC1>[ClH:39].[NH2:32][CH:33]1[CH2:38][CH2:37][N:36]([C:16]2[N:17]=[C:12]([NH:11][C:5]3[CH:4]=[C:3]([O:2][CH3:1])[CH:8]=[C:7]([O:9][CH3:10])[CH:6]=3)[C:13]3[C:23](=[O:24])[NH:22][CH:21]=[CH:20][C:14]=3[N:15]=2)[CH2:35][CH2:34]1
ParticipantsProcedureSources & evidenceReaction notes

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 7238334-(N-Boc-amino)piperidineHCID 66984885HCID 66984885, compound

Product 1

HCID 66985215HCID 66985215, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The title compound (Compound 3; MS m/z: 398 (M+H)+) was prepared as described in Example 1g starting from 4-(3,5-dimethoxyphenylamino)-2-(methylthio)pyrido[4,3-d]pyrimidin-5(6H)-one (40 mg, 0.29 mmol) and 4-(boc-amino) piperidine and treating with 4 N HCl in dioxane (17 mg).

Sources & evidence

ORD record
ord-f1de74ed35524c169c4829898df0bd86
Source dataset
uspto-grants-2013_03
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US08404677B2

Reaction notes

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On this pageParticipantsProcedureSources & evidenceReaction notes