Benzoyl isothiocyanate → [3-(3-Benzoyl-thioureido)-pyrazol-1-yl]-acetic acid tert-butyl ester
Reaction equation
[C:1]([O:5][C:6](=[O:14])[CH2:7][N:8]1[CH:12]=[CH:11][C:10]([NH2:13])=[N:9]1)([CH3:4])([CH3:3])[CH3:2].[C:15]([N:23]=[C:24]=[S:25])(=[O:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[C:1]([O:5][C:6](=[O:14])[CH2:7][N:8]1[CH:12]=[CH:11][C:10]([NH:13][C:24]([NH:23][C:15](=[O:22])[C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)=[S:25])=[N:9]1)([CH3:4])([CH3:2])[CH3:3]Participants
3
Procedure
(3-Amino-pyrazol-1-yl)-acetic acid tert-butyl ester (1.05 g, 5.33 mmol) is added dropwise under argon to a stirred solution of benzoyl isothiocyanate (0.754 ml, 5.4 mmol). After stirring for 5 minutes the reaction mixture is poured onto water and the titled compound, a yellow precipitate, is collected and dried.
Workup
- additionis poured onto water
- customthe titled compound, a yellow precipitate, is collected
- customdried