Ammonium Hydroxide → 5-Methylfuran-3-carboxamide
Reaction equation
[CH3:1][C:2]1[O:6][CH:5]=[C:4]([C:7](Cl)=[O:8])[CH:3]=1.[OH-].[NH4+:11]>C1C=CC=CC=1>[CH3:1][C:2]1[O:6][CH:5]=[C:4]([C:7]([NH2:11])=[O:8])[CH:3]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
24.7 g (171 mmol) of 5-methylfuran-3-carbonyl chloride were added dropwise to a stirred mixture of 80 ml of a 25% strength ammonium hydroxide solution and 80 ml of benzene at 25-40° C. The resulting mixture was stirred for 3 h and left to stand overnight. The next day, white crystals of the amide were filtered off, washed with cold water and dried to constant weight at 40-45° C. Yield 19.7 g (158 mmol, 92%), melting point 158° C.
Workup
- waitleft
- waitto stand overnight
- filtrationThe next day, white crystals of the amide were filtered off
- washwashed with cold water
- customdried to constant weight at 40-45° C
Sources & evidence
- ORD record
- ord-2bda9bdd4c5540808b551e7da104171c
- Source dataset
- uspto-grants-2000_09
- Patent number
- US06114358
Reaction notes
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