Oxalic Acid → 7-Fluoro-5-methyl-1,2,3,4-tetrahydroquinoxaline-2,3-dione
Reaction equation
[NH2:1][C:2]1[C:7]([NH2:8])=[CH:6][C:5]([F:9])=[CH:4][C:3]=1[CH3:10].[C:11](O)(=[O:15])[C:12](O)=[O:13]>Cl.O>[F:9][C:5]1[CH:6]=[C:7]2[C:2]([NH:1][C:11](=[O:15])[C:12](=[O:13])[NH:8]2)=[C:3]([CH3:10])[CH:4]=1Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
20 g (0.118 mol) of 2,3-diamino-5-fluorotoluene and 15.8 g (0.176 mol) of oxalic acid are stirred at reflux for 16 hours in 4N hydrochloric acid. The reaction mixture is cooled, diluted with water, filtered off on a suction filter and washed with water. The title compound is obtained as beige crystals of m.p.>300° C.
Workup
- temperatureThe reaction mixture is cooled
- filtrationfiltered off on a suction
- filtrationfilter
- washwashed with water
Sources & evidence
- ORD record
- ord-1fbbc6035fac439cbe359fc4f3f6efb6
- Source dataset
- uspto-grants-2000_09
- Patent number
- US06117873
Reaction notes
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