Hydrochloric Acid → HCID 178508892, compound
Reaction equation
C([O:3][C:4](=[O:35])[CH2:5][NH:6][S:7]([C:10]1[S:11][C:12]([CH2:15][CH2:16][CH:17]2[CH2:34][NH:33][C:20]3[N:21]=[C:22]([NH:26]C(=O)C(C)(C)C)[N:23]=[C:24]([OH:25])[C:19]=3[CH2:18]2)=[CH:13][CH:14]=1)(=[O:9])=[O:8])C.Cl>[OH-].[Na+]>[NH2:26][C:22]1[N:23]=[C:24]([OH:25])[C:19]2[CH2:18][CH:17]([CH2:16][CH2:15][C:12]3[S:11][C:10]([S:7]([NH:6][CH2:5][C:4]([OH:35])=[O:3])(=[O:8])=[O:9])=[CH:14][CH:13]=3)[CH2:34][NH:33][C:20]=2[N:21]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 33 mg (0.062 mmol) of N-{5-[2-(2-pivaloylamino-4-hydroxy-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl)-ethyl]thien-2-ylsulfonyl}glycine ethyl ester in 3.0 mL of 1.0N sodium hydroxide was stirred at room temperature for 24 hours. The reaction mixture was then acidified with 1.0N hydrochloric acid and the white precipitate was collected by filtration to give 28 mg of N-{5-[2-(2-amino-4-hydroxy-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl)-ethyl]thien-2-ylsulfonyl}glycine.