[3-(8-Isopropyl-5-methyl-6-oxo-5,6,7,8-tetrahydro-pteridin-2-ylamino)-5-(methylsulfonyl)-phenyl]-thiocarbamic acid ethyl ester → (4-[3-[3-(8-Isopropyl-5-methyl-6-oxo-5,6,7,8-tetrahydro-pteridin-2-ylamino)-5-(methylsulfonyl)-phenyl]-ureido]-cyclohexyl)-carbamic acid tert butyl ester

Reaction equation

C([O:3][C:4](=S)[NH:5][C:6]1[CH:11]=[C:10]([S:12]([CH3:15])(=[O:14])=[O:13])[CH:9]=[C:8]([NH:16][C:17]2[N:26]=[CH:25][C:24]3[N:23]([CH3:27])[C:22](=[O:28])[CH2:21][N:20]([CH:29]([CH3:31])[CH3:30])[C:19]=3[N:18]=2)[CH:7]=1)C.[C:33]([O:37][C:38](=[O:47])[NH:39][C@H:40]1[CH2:45][CH2:44][C@@H:43]([NH2:46])[CH2:42][CH2:41]1)([CH3:36])([CH3:35])[CH3:34]>CN(C=O)C.O>[C:33]([O:37][C:38](=[O:47])[NH:39][CH:40]1[CH2:41][CH2:42][CH:43]([NH:46][C:4]([NH:5][C:6]2[CH:11]=[C:10]([S:12]([CH3:15])(=[O:14])=[O:13])[CH:9]=[C:8]([NH:16][C:17]3[N:26]=[CH:25][C:24]4[N:23]([CH3:27])[C:22](=[O:28])[CH2:21][N:20]([CH:29]([CH3:31])[CH3:30])[C:19]=4[N:18]=3)[CH:7]=2)=[O:3])[CH2:44][CH2:45]1)([CH3:36])([CH3:34])[CH3:35]