Sodium Thiosulfate → HCID 59443055, compound
Reaction equation
C1C=C[NH+]=CC=1.[Br:7][Br-]Br.[Cl:10][C:11]1[CH:20]=[C:19]2[C:14]([C:15]([C:23]3[CH:28]=[CH:27][C:26]([F:29])=[CH:25][CH:24]=3)=[CH:16][C:17]([CH3:22])([CH3:21])[O:18]2)=[CH:13][CH:12]=1.S([O-])([O-])(=O)=S.[Na+].[Na+]>ClCCl>[Br:7][C:16]1[C:17]([CH3:21])([CH3:22])[O:18][C:19]2[C:14]([C:15]=1[C:23]1[CH:24]=[CH:25][C:26]([F:29])=[CH:27][CH:28]=1)=[CH:13][CH:12]=[C:11]([Cl:10])[CH:20]=2Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Pyridinium bromide perbromide (1.00 g) was added to a solution of 7-chloro-4-(4-fluorophenyl)-2,2-dimethyl-2H-chromen (a compound obtained in Reference Example 5(3); 1.00 g) in dichloromethane (15 mL) under ice-cooling and the mixture was stirred at room temperature for 1.5 hours. The reaction mixture was poured into a 15% aqueous solution of sodium thiosulfate and extracted with ethyl acetate. The organic layer was washed successively with a saturated solution of sodium bicarbonate and brine, dried over sodium sulfate and concentrated in vacuo. The resultant residue was purified by column chromatography on silica gel (Solvent: n-hexane/chloroform=100/0 to 95/5) to give the titled compound (1.26 g) as a colorless powder.