1-Methylpiperazine → 1-(4-Bromobenzoyl)-4-methylpiperazine

HRID 1961510Notes

Reaction equation

[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][CH:3]=1.[CH3:11][N:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:15]2[CH2:16][CH2:17][N:12]([CH3:11])[CH2:13][CH2:14]2)=[O:7])=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 531671-Methylpiperazine

HCID 685154-Bromobenzoyl chloride

Product 1

HCID 44643521-(4-Bromobenzoyl)-4-methylpiperazine

Procedure

1-(4-bromobenzoyl)-4-methylpiperazine was prepared according to the general procedure in Example 4 Step 1 using 4-bromobenzoyl chloride (1 g, 4.56 mmol) and 1-methylpiperazine (0.532 mL, 4.78 mmol) as the starting materials.

Sources & evidence

ORD record: ord-c87dc570fb0e4e4f99d8fae938f2b88f
Source dataset: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08415346B2

Reaction notes

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