HomeMCPWorkbenchSkills
HomeWorkbenchNotificationsMe
llms.txt · MCP GuidePrivacy Policy · Terms of Service · Supportv1.8.0
  1. Home
  2. /Reaction

3-(Boc-amino)piperidine → Hydrochloric Acid

HRID 1962423
Notes
Print preview

Reaction equation

HRID 1962423 reaction equation
C(OC([NH:8][CH:9]1[CH2:14][CH2:13][CH2:12][N:11]([S:15]([C:18]2[C:19]3[C:20]([Br:28])=[CH:21][N:22]=[CH:23][C:24]=3[CH:25]=[CH:26][CH:27]=2)(=[O:17])=[O:16])[CH2:10]1)=O)(C)(C)C.BrC1C2C(S([Cl:43])(=O)=O)=CC=CC=2C=NC=1.C(OC(NC1CCCNC1)=O)(C)(C)C>>[NH2:8][CH:9]1[CH2:14][CH2:13][CH2:12][N:11]([S:15]([C:18]2[C:19]3[C:20]([Br:28])=[CH:21][N:22]=[CH:23][C:24]=3[CH:25]=[CH:26][CH:27]=2)(=[O:17])=[O:16])[CH2:10]1.[ClH:43]
ParticipantsProcedureSources & evidenceReaction notes

Participants

5

Reactant 3

HCID 42330413-(Boc-amino)piperidineHCID 145800584-Bromo-5-isoquinolinesulfonyl chlorideHCID 67242812(r/s)-3-(Tert-butoxycarbonylamino)-1-(4-bromo-5-isoquinolinesulfonyl)piperidine2×

Product 2

HCID 313Hydrochloric AcidHCID 67242500(r/s)-3-Amino-1-(4-bromo-5-isoquinolinesulfonyl)piperidine

Procedure

(R/S)-3-(tert-Butoxycarbonylamino)-1-(4-bromo-5-isoquinolinesulfonyl)-piperidine (Intermediate 2) can be prepared from 4-bromo-5-isoquinolinesulfonyl chloride and 3-(tert-butoxycarbonylamino)piperidine (AstaTech) according to the method described in Example 1-1, Step A, and then used in the method of Example 1-1, Step B in a similar manner to obtain the title compound as hydrochloride.

Sources & evidence

ORD record
ord-97b4ba54a12946a5a63ca0acd31cca39
Source dataset
uspto-grants-2013_04
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US08415372B2

Reaction notes

Loading…

On this pageParticipantsProcedureSources & evidenceReaction notes