Lithium Bromide → 1-Bromo-3-(3-fluoro-2-methyl-phenyl)-propan-2-one
Reaction equation
Cl[CH2:2][C:3](=[O:13])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:6]=1[CH3:12].[Br-:14].[Li+]>CC(C)=O>[Br:14][CH2:2][C:3](=[O:13])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:6]=1[CH3:12]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
The compound of step 1 (3.20 g, 15.95 mmol) was dissolved in acetone (70 ml), and lithium bromide (11.08 g, 127.59 mmol) was added. The mixture was stirred overnight. The solvent was evaporated, the resulting solid was dissolved in EA and the solution washed twice with water followed by a saturated solution of sodium chloride, dried over sodium sulfate, filtered and evaporated to dryness. 3.66 g of the title compound were obtained as a white powder.
Workup
- customThe solvent was evaporated
- dissolutionthe resulting solid was dissolved in EA
- washthe solution washed twice with water
- dry with materialdried over sodium sulfate
- filtrationfiltered
- customevaporated to dryness
Sources & evidence
- ORD record
- ord-0017813294b64f21afa9f508a322291c
- Source dataset
- uspto-grants-2013_04
- Patent number
- US08415336B2
Reaction notes
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