Ethyl Bromide → 5-bromo-N-ethyl-2-methylaniline

Reaction equation

Br[CH2:2][CH3:3].[Br:4][C:5]1[CH:6]=[CH:7][C:8]([CH3:12])=[C:9]([CH:11]=1)[NH2:10]>>[Br:4][C:5]1[CH:6]=[CH:7][C:8]([CH3:12])=[C:9]([CH:11]=1)[NH:10][CH2:2][CH3:3]

Participants

Reactant 2

HCID 6332Ethyl Bromide

HCID 27348055-Bromo-o-toluidine

Product 1

HCID 437296995-bromo-N-ethyl-2-methylanilineYield 71%

Procedure

Using the same method as in Example 22-(i), bromoethane was reacted with the 5-bromo-2-methylaniline to give 5-bromo-N-ethyl-2-methylaniline (yield: 71%).

Sources & evidence

ORD record: ord-ea85080ab9de409f82c76c06ede6d6dc
Source dataset: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08415479B2

Reaction notes

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