Iodine → HCID 178516519, compound
Reaction equation
[OH:1][C:2]1[CH:7]=[C:6]([OH:8])[CH:5]=[CH:4][N:3]=1.C([O-])([O-])=O.[K+].[K+].[I:15]I.OS([O-])(=O)=O.[K+]>O>[OH:1][C:2]1[C:7]([I:15])=[C:6]([OH:8])[CH:5]=[CH:4][N:3]=1Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 100 °C
Procedure
A mixture of 2,4-dihydroxypyridine (1.0 eq), K2CO3 (1.0 eq), and water was stirred at 100° C. so that it became homogeneous. With continued stirring and heating, I2 (1.0 eq) was added in portions, causing the evolution of gas. When the solid I2 was consumed, the mixture was cooled and acidified with aqueous KHSO4 (1.0 eq), generating a precipitate. The precipitate was collected by filtration, rinsed with water, and stored under high vacuum, to give 2,4-dihydroxy-3-iodopyridine.
Workup
- stirringWith continued stirring
- temperatureheating
- customWhen the solid I2 was consumed
- temperaturethe mixture was cooled
- filtrationThe precipitate was collected by filtration
- washrinsed with water
Sources & evidence
- ORD record
- ord-c55d733421a444529c3510bfaeac415c
- Source dataset
- uspto-grants-2010_06
- Patent number
- US07745454B2
Reaction notes
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