Tetrahydrofuran → Tert-butyl 4-(4-chloro-3-methoxyphenyl)-4-hydroxy-3,3-dimethylpiperidine-1-carboxylate

HRID 196606

Reaction equation

HRID 196606 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([Cl:10])[c:6]([O:8][CH3:9])[cH:7]1.[CH2:11]([Li:12])[CH2:13][CH2:14][CH3:15].[CH2:32]1[O:33][CH2:34][CH2:35][CH2:36]1.[CH3:16][C:17]1([CH3:31])[CH2:18][N:19]([C:24](=[O:25])[O:26][C:27]([CH3:28])([CH3:29])[CH3:30])[CH2:20][CH2:21][C:22]1=[O:23]>>[c:2]1([C:22]2([OH:23])[C:17]([CH3:16])([CH3:31])[CH2:18][N:19]([C:24](=[O:25])[O:26][C:27]([CH3:28])([CH3:29])[CH3:30])[CH2:20][CH2:21]2)[cH:3][cH:4][c:5]([Cl:10])[c:6]([O:8][CH3:9])[cH:7]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 27695675-Bromo-2-chloroanisoleHCID 22278899tert-Butyl 3,3-dimethyl-4-oxopiperidine-1-carboxylateHCID 178418339Butyllithium

Product 1

HCID 57889543Tert-butyl 4-(4-chloro-3-methoxyphenyl)-4-hydroxy-3,3-dimethylpiperidine-1-carboxylate

Sources & evidence

ORD record
ord-31fc804b5f924f9ea3ea56d4c9347f6b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Linked notes

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