Toluene → 6-(2-Fluorophenyl)nicotinic acid

HRID 196829

Reaction equation

HRID 196829 reaction equation
[CH3:28][c:29]1[cH:30][cH:31][cH:32][cH:33][cH:34]1.[Cl:35][CH2:36][Cl:37].[F:1][c:2]1[c:3](-[c:8]2[n:9][cH:10][c:11]([C:12](=[O:13])[O:14][C:15]([CH3:16])([CH3:17])[CH3:18])[cH:19][cH:20]2)[cH:4][cH:5][cH:6][cH:7]1.[F:21][C:22]([F:23])([F:24])[C:25]([OH:26])=[O:27]>>[F:1][c:2]1[c:3](-[c:8]2[n:9][cH:10][c:11]([C:12](=[O:13])[OH:14])[cH:19][cH:20]2)[cH:4][cH:5][cH:6][cH:7]1

Participants

5

Reactant 4

HCID 1140TolueneHCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 67267995Tert-butyl 6-(2-fluorophenyl)nicotinate

Product 1

HCID 247299716-(2-Fluorophenyl)nicotinic acid

Sources & evidence

ORD record
ord-0d058fdc0bb74ce88f9300b96dd61641
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Linked notes

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