Trifluoroacetic acid → Guanidinium trifluoroacetate
Reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].C(=O)(O)O.[NH2:12][C:13]([NH2:15])=[NH:14]>O>[O-:5][C:3]([C:2]([F:7])([F:6])[F:1])=[O:4].[NH2:14][C:13]([NH2:15])=[NH2+:12]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 90 °C
Procedure
Trifluoroacetic acid (50.0 ml, 74.0 g, 649 mmol) was added to 500 ml of distilled water in a 4-liter beaker with stirring. Guanidine carbonate (58.5 g, 324.5 mmol) was added at room temperature in portions with stirring as to avoid bubbling over the sides of the beaker due to the evolution of carbon dioxide. The reaction was stirred at room temperature for 2 hours. The water was removed in vacuo with heating to approximately 90° C. for 4 hours. The product was recovered as a white crystalline solid.
Workup
- stirringwith stirring as
- customto avoid bubbling over the sides of the beaker due to the evolution of carbon dioxide
- stirringThe reaction was stirred at room temperature for 2 hours
- customThe water was removed in vacuo
- customThe product was recovered as a white crystalline solid
Sources & evidence
- ORD record
- ord-0c5b08fa01a1450c8463885752b10087
- Source dataset
- uspto-grants-2013_04
- Patent number
- US08425702B2
Reaction notes
Loading…