Potassium Carbonate → N,N-dimethyl-2-(4-nitro-1H-pyrazol-1-yl)ethanamine
Reaction equation
Cl.[CH3:2][N:3]([CH3:7])[CH2:4][CH2:5]Cl.C(=O)([O-])[O-].[K+].[K+].[N+:14]([C:17]1[CH:18]=[N:19][NH:20][CH:21]=1)([O-:16])=[O:15]>CC(C)=O>[CH3:2][N:3]([CH3:7])[CH2:4][CH2:5][N:19]1[CH:18]=[C:17]([N+:14]([O-:16])=[O:15])[CH:21]=[N:20]1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
2-Dimethylaminoethyl chloride hydrochloride (955 mg, 6.63 mmol), potassium carbonate (1.83 g, 8.84 mmol) and 4-nitro-1H-pyrazole (750 mg, 6.63 mmol) were combined in acetone (30 ml) and the reaction was stirred overnight at reflux. After cooling to room temperature, the crude reaction mixture was filtered to remove inorganics, and the filtrate was concentrated to give the product.
Workup
- temperatureat reflux
- customthe crude reaction mixture
- filtrationwas filtered
- customto remove inorganics
- concentrationthe filtrate was concentrated
- customto give the product
Sources & evidence
- ORD record
- ord-90cd9357aed94eada62ef2c2cd7b9c0b
- Source dataset
- uspto-grants-2013_04
- Patent number
- US08426408B2
Reaction notes
Loading…