Ammonia → HCID 86643508, compound
Reaction equation
[CH2:1]([N:3]([C:10]1[CH:19]=[CH:18][CH:17]=[C:16]2[C:11]=1[CH:12]=[CH:13][CH:14]=[C:15]2[S:20](Cl)(=[O:22])=[O:21])[C:4](=[O:9])[C:5]([F:8])([F:7])[F:6])[CH3:2].[NH3:24]>O1CCCC1>[CH2:1]([N:3]([C:10]1[C:11]2[C:16](=[C:15]([S:20](=[O:22])(=[O:21])[NH2:24])[CH:14]=[CH:13][CH:12]=2)[CH:17]=[CH:18][CH:19]=1)[C:4](=[O:9])[C:5]([F:8])([F:7])[F:6])[CH3:2]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 0 °C
Procedure
5-(N-ethyl-2,2,2-trifluoroacetamido)naphthalene-1-sulfonyl chloride (100 mg) was dissolved in tetrahydrofuran (1.0 mL), cooled to 0° C., then concentrated ammonia (0.11 mL) was added. The reaction was stirred at 0° C. for 3 hours, then concentrated and partitioned between water and ethyl acetate. The organic layer was dried over Na2SO4, filtered, and concentrated to give the title compound.