3-Butoxycarbonylamino-pyrrolidine-1-carboxylic acid benzyl ester → Pyrrolidin-3-yl-carbamic acid butyl ester
Reaction equation
C(OC([N:11]1[CH2:15][CH2:14][CH:13]([NH:16][C:17]([O:19][CH2:20][CH2:21][CH2:22][CH3:23])=[O:18])[CH2:12]1)=O)C1C=CC=CC=1>C(OCC)(=O)C.[Pd]>[CH2:20]([O:19][C:17](=[O:18])[NH:16][CH:13]1[CH2:14][CH2:15][NH:11][CH2:12]1)[CH2:21][CH2:22][CH3:23]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
A solution of 467 mg 3-butoxycarbonylamino-pyrrolidine-1-carboxylic acid benzyl ester in 10 ml ethyl acetate was stirred in the presence of 100 mg Pd/C (10%) under an atmosphere of hydrogen (1 bar) for 12 h. The reaction mixture was filtrated, washed with ethyl acetate and concentrated to give the title compound as colorless oil.
Workup
- filtrationThe reaction mixture was filtrated
- washwashed with ethyl acetate
- concentrationconcentrated
Sources & evidence
- ORD record
- ord-bea721c1ac824d4b9b92af0dde2109ba
- Source dataset
- uspto-grants-2013_04
- Patent number
- US08426420B2
Reaction notes
Loading…