Ammonium Acetate → 1,3-Thiazol-2-ylthiourea
Reaction equation
[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[NH:6][C:7]([N:9]1C=CN=C1)=[S:8].C([O-])(=O)C.[NH4+]>C(O)C>[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[NH:6][C:7]([NH2:9])=[S:8]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of 65 g (309.1 mmol) N-1,3-thiazole-2-yl-1H-imidazole-1-carbothioamide and 260 g of ammonium acetate were heated to 80° C. in 400 ml ethanol for 1.5 hours; after completion of reaction the solvent was distilled off and water was added to the obtained residue. After extraction with CH2Cl2 and drying of the organic phase with Na2SO4, 59.6 g of the target product were obtained.
Workup
- customafter completion of reaction the solvent
- distillationwas distilled off
- additionwater was added to the obtained residue
- extractionAfter extraction with CH2Cl2
- dry with materialdrying of the organic phase with Na2SO4
Sources & evidence
- ORD record
- ord-bf35adfbf8df4464b5735cef14e6b56c
- Source dataset
- uspto-grants-2013_04
- Patent number
- US08431604B2
Reaction notes
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