Tert-Butylamine → HCID 58124811, compound
Reaction equation
CS(O[CH2:6][CH2:7][CH2:8][C:9]#[C:10][C:11]1[S:12][CH:13]=[CH:14][CH:15]=1)(=O)=O.[C:16]([NH2:20])([CH3:19])([CH3:18])[CH3:17]>>[C:16]([NH:20][CH2:6][CH2:7][CH2:8][C:9]#[C:10][C:11]1[S:12][CH:13]=[CH:14][CH:15]=1)([CH3:19])([CH3:18])[CH3:17]Participants
3
Procedure
A mixture of 210 mg of 2b and 5 ml of tert-butyl amine was stirred for 4 days. The reaction mixture was concentrated and the residue was treated with 20 ml of 1M K2CO3 and the product was extracted into ethyl acetate. The organic layer was washed once with water, dried and concentrated, to provide 250 mg of 2c as a colorless oil.
Workup
- concentrationThe reaction mixture was concentrated
- additionthe residue was treated with 20 ml of 1M K2CO3
- extractionthe product was extracted into ethyl acetate
- washThe organic layer was washed once with water
- customdried
- concentrationconcentrated
Sources & evidence
- ORD record
- ord-8e0de67fab5d417e84bc9474c78ac7a0
- Source dataset
- uspto-grants-2013_04
- Patent number
- US08431564B2
Reaction notes
Loading…