Hydrochloric Acid → 4-(4-Benzyloxy-phenyl)-3-butyl-6-(piperidin-4-yloxy)-pyridazine dihydrochloride
Reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[N:16]=[N:17][C:18]([CH2:35][CH2:36][CH2:37][CH3:38])=[C:19]([C:21]3[CH:26]=[CH:25][C:24]([O:27][CH2:28][C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=4)=[CH:23][CH:22]=3)[CH:20]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:39]>O1CCOCC1>[ClH:39].[ClH:39].[CH2:28]([O:27][C:24]1[CH:25]=[CH:26][C:21]([C:19]2[CH:20]=[C:15]([O:14][CH:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]3)[N:16]=[N:17][C:18]=2[CH2:35][CH2:36][CH2:37][CH3:38])=[CH:22][CH:23]=1)[C:29]1[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
4-[5-(4-Benzyloxy-phenyl)-6-butyl-pyridazin-3-yloxy]-piperidine-1-carboxylic acid tert-butyl ester (0.50 mmol, 260 mg) was dissolved in 4.0 M HCl in dioxane and stirred for 45 min at room temperature. The solvent was evaporated, and the resultant solid was washed with ether and dried to provide 4-(4-benzyloxy-phenyl)-3-butyl-6-(piperidin-4-yloxy)-pyridazine dihydrochloride.