Pyridoxine Hydrochloride → Pyridoxine

HRID 1972117

Reaction equation

HRID 1972117 reaction equation
[CH3:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][OH:9])=[C:4]([CH2:10][OH:11])[C:3]=1[OH:12].Cl>O>[CH3:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][OH:9])=[C:4]([CH2:10][OH:11])[C:3]=1[OH:12]

Participants

3

Reactant 1

HCID 6019Pyridoxine Hydrochloride

Product 1

HCID 1054Pyridoxine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

In a second alternative and preferred workup, the reaction mixture (following complete conversion to compound (C)) is cooled to 20° C. and diluted with water (approximately 2.80 L of water for every 1 kg of starting pyridoxine HCl). After phase separation the organic phase is washed with water. The combined aqueous phases are reextracted twice with TBME. The combined TBME phases are washed once with saturated NaHCO3-solution and once with diluted brine. The MTBE-product solution is concentrated to a concentration of about 50% and stored at room temperature until it is further converted. If this second alternative workup is used, the volume of MTBE in the synthetic step is preferably reduced by about 26%.

Workup

  1. customAfter phase separation the organic phase
  2. washis washed with water
  3. washThe combined TBME phases are washed once with saturated NaHCO3-solution and once with diluted brine
  4. concentrationThe MTBE-product solution is concentrated to a concentration of about 50%
  5. customstored at room temperature until it

Sources & evidence

ORD record
ord-cc4bff35dda74e18b4029cc32dff8e2f
Source dataset
uspto-grants-2013_04
Patent number
US08431712B2

Linked notes

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