Hydrochloric Acid → Phenethylamine, alpha,alpha-dimethyl-4-dimethylamino-, dihydrochloride
Reaction equation
[CH3:1][C:2]([NH:14]C(=O)C)([CH3:13])[CH2:3][C:4]1[CH:9]=[CH:8][C:7]([N:10]([CH3:12])[CH3:11])=[CH:6][CH:5]=1.[ClH:18]>O>[ClH:18].[ClH:18].[CH3:12][N:10]([CH3:11])[C:7]1[CH:8]=[CH:9][C:4]([CH2:3][C:2]([NH2:14])([CH3:13])[CH3:1])=[CH:5][CH:6]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 3.5 of N-[α, α-dimethyl-β-(4-dimethylaminophenyl) ethyl]acetamide in a mixture of 25 ml of water and 25 ml of concentrated hydrochloric acid is reluxed for 16 hours. The solution is then evaporated under reduced pressure and the residue is recrystallized twice from methanol isopropyl ether. Yield: 1.1 g, m.p. 239,5°-240,5°.
Workup
- customThe solution is then evaporated under reduced pressure
- customthe residue is recrystallized twice from methanol isopropyl ether
Sources & evidence
- ORD record
- ord-b1f78afda1d940c9a3edc7cd831de829
- Source dataset
- uspto-grants-1976_12
- Patent number
- US03996381
Reaction notes
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