Acetone → HCID 21490924, compound
Reaction equation
[OH:1][CH2:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[C:6]([CH2:11][CH2:12][CH2:13][CH3:14])=[CH:5][N:4]=1.[ClH:15].CC(C)=O>CO.CCOCC>[ClH:15].[OH:1][CH2:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[C:6]([CH2:11][CH2:12][CH2:13][CH3:14])=[CH:5][N:4]=1Participants
6
Reactant 3
Product 1
Reagents, catalysts & solvents 2
Procedure
A solution of 2-hydroxymethyl-4-methoxy-5-n-butyl-pyridine in methanol is adjusted to pH 1 with hydrochloric acid in ether and evaporated to dryness. The water which still adheres is distilled off azeotropically with toluene. The residue thus obtained is digested with acetone and the crystalline product is filtered off. 2-Hydroxymethyl-4-methoxy-5-n-butyl-pyridine hydrochloride of melting point 136°-137° is thus obtained.
Workup
- customevaporated to dryness
- distillationThe water which still adheres is distilled off azeotropically with toluene
- customThe residue thus obtained
- filtrationthe crystalline product is filtered off
Sources & evidence
- ORD record
- ord-aeed5e8fff4941e58bb877b6c0ed57ff
- Source dataset
- uspto-grants-1976_12
- Patent number
- US03998955
Reaction notes
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