Acetic acid, [(4-fluoro-2-nitrophenyl)amino]oxo-, ethyl ester → 7-fluoro-1-hydroxyquinoxaline-2,3-(1H,4H)-dione
Reaction equation
[C:1]([NH:8][C:9]1[CH:14]=[CH:13][C:12]([F:15])=[CH:11][C:10]=1[N+:16]([O-:18])=O)([C:3](OCC)=[O:4])=[O:2]>[Pd].CN(C=O)C>[F:15][C:12]1[CH:11]=[C:10]2[C:9]([NH:8][C:1](=[O:2])[C:3](=[O:4])[N:16]2[OH:18])=[CH:14][CH:13]=1Participants
4
Procedure
To a mixture of 5.6 g of 2-ethoxalylamino-5-fluoronitrobenzene and 170 ml of DMF was added 0.3 g of 10% Pd-C, and hydrogenation reaction was carried out at ordinary temperature and pressure. The reaction mixture was then filtered and concentrated under reduced pressure. The resulting residue was recrystallized from ethanol to provide 3.68 g (85%) of 7-fluoro-1-hydroxyquinoxaline-2,3-(1H,4H)-dione
Workup
- additionwas added
- filtrationThe reaction mixture was then filtered
- concentrationconcentrated under reduced pressure
- customThe resulting residue was recrystallized from ethanol
Sources & evidence
- ORD record
- ord-068db328e3d749cb93d3bc464b49f557
- Source dataset
- uspto-grants-1994_02
- Patent number
- US05283244
Reaction notes
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