Hydrochloric Acid → 4-((Dimethylamino)methyl)-4-piperidinol dihydrochloride

Reaction equation

[CH3:1][N:2]([CH2:4][C:5]1([OH:16])[CH2:10][CH2:9][N:8](C(OCC)=O)[CH2:7][CH2:6]1)[CH3:3].[ClH:17]>>[ClH:17].[ClH:17].[CH3:3][N:2]([CH2:4][C:5]1([OH:16])[CH2:6][CH2:7][NH:8][CH2:9][CH2:10]1)[CH3:1]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 19382159HCID 19382159, compound

Product 1

HCID 193822164-((Dimethylamino)methyl)-4-piperidinol dihydrochloride

Procedure

4.5 g (19.4 mmol) of ethyl 4-dimethylaminomethyl-4-hydroxypiperidine-1-carboxylate are heated overnight under reflux with 35 ml of concentrated hydrochloric acid. The product is concentrated, and the crystals are triturated with acetone, filtered off with suction and dried in a vacuum desiccator over P4O10.

Workup

concentrationThe product is concentrated
customthe crystals are triturated with acetone
filtrationfiltered off with suction
dry with materialdried in a vacuum desiccator over P4O10

Sources & evidence

ORD record: ord-09706ab2dac248c9b2ece0af30bd9028
Source dataset: uspto-grants-1994_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05284842

Reaction notes

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