HCID 19100958, compound → 1-Phenyloctahydropyrrolo[3,4-b]pyrrole
Reaction equation
[C:1]1([N:7]2[CH2:14][CH2:13][CH:12]3[CH:8]2[CH2:9][N:10](C(OCC)=O)[CH2:11]3)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>Cl>[C:1]1([N:7]2[CH2:14][CH2:13][CH:12]3[CH:8]2[CH2:9][NH:10][CH2:11]3)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
7.6 g (31.6 mmol) of ethyl 2-phenyl-2,7-diazabicyclo[3.3.0]octane-7-carboxylate together with 50 ml of concentrated hydrochloric acid are refluxed overnight. The mixture is concentrated, the residue is taken up in 50 ml of 10% strength sodium hydroxide solution, and this mixture is extracted five times using 50 ml portions of chloroform. The extracts are dried over potassium carbonate and concentrated, and the residue is distilled.
Workup
- concentrationThe mixture is concentrated
- extractionthis mixture is extracted five times
- dry with materialThe extracts are dried over potassium carbonate
- concentrationconcentrated
- distillationthe residue is distilled
Sources & evidence
- ORD record
- ord-3d5e8bafc9e3483bbdee8367673dcd83
- Source dataset
- uspto-grants-1994_02
- Patent number
- US05284855
Reaction notes
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