Water → 1-(3,5-Dimethylphenoxy)-2-propanone oxime

HRID 1975542Notes

Reaction equation

HRID 1975542 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH:10]=[C:11]([CH3:13])[CH:12]=1)[O:5][CH2:6][C:7](=O)[CH3:8].S(O)(O)(=O)=O.[NH2:19][OH:20].C(=O)([O-])O.[Na+].O>C(O)C>[CH3:1][C:2]1[CH:3]=[C:4]([CH:10]=[C:11]([CH3:13])[CH:12]=1)[O:5][CH2:6][C:7](=[N:19][OH:20])[CH3:8]

Participants

6

Reactant 4

HCID 962WaterHCID 159255Hydroxylamine, sulfate (1:1)HCID 3088301-(3,5-Dimethylphenoxy)propan-2-oneHCID 516892Sodium Bicarbonate

Product 1

HCID 731208521-(3,5-Dimethylphenoxy)-2-propanone oximeYield 155.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

10.0 Grams (56 mmol) of 1-(3,5-dimethylphenoxy)-2-propanone was dissolved in 50 ml of ethanol, and 5.53 g (34 mmol) of hydroxylamine sulfate and 5.66 g (67 mmol) of sodium hydrogencarbonate were added. And, the resultant mixture was stirred at room temperature for 4 hours, and 50 ml of water was added. Ethanol was distilled off under reduced pressure, and the resultant solid precipitate was recovered by filtration, washed with water and dried to give 10.2 g of 1-(3,5-dimethylphenoxy)-2-propanone oxime (yield 92%).

Workup

  1. distillationEthanol was distilled off under reduced pressure
  2. filtrationthe resultant solid precipitate was recovered by filtration
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-da762cef694e4036a3a81a3b60f80298
Source dataset
uspto-grants-1994_02
Patent number
US05286905

Reaction notes

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