Lithium Chloride → 3-Chloro-1,1,1,2,2-Pentafluoropropane

HRID 1975799

Reaction equation

HRID 1975799 reaction equation
[Cl-:1].[Li+].[F:3][C:4]([F:21])([C:17]([F:20])([F:19])[F:18])[CH2:5]OS(C1C=CC(C)=CC=1)(=O)=O>CN1CCCC1=O>[Cl:1][CH2:5][C:4]([F:21])([F:3])[C:17]([F:20])([F:19])[F:18]

Participants

4

Reactant 2

HCID 433294Lithium ChlorideHCID 27760172,2,3,3,3-Pentafluoropropyl p-Toluenesulfonate

Product 1

HCID 679053-Chloro-1,1,1,2,2-Pentafluoropropane

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

Until HCFC-225ca becomes available in commercial quantities, HCFC-225ca may be prepared by a standard and well-known organic synthesis technique. For example, to prepare 1,1-dichloro-2,2,3,3,3-pentafluoropropane, 2,2,3,3,3-pentafluoro-1-propanol and p-toluenesulfonate chloride are reacted together to form 2,2,3,3,3-pentafluoropropyl-p-toluenesulfonate. Then, N-methylpyrrolidone, lithium chloride, and the 2,2,3,3,3-pentafluoropropyl-p-toluenesulfonate are reacted together to form 1-chloro-2,2,3,3,3-pentafluoropropane. Chlorine and the 1-chloro-2,2,3,3,3-pentafluoropropane are then reacted together to form 1,1-dichloro-2,2,3,3,3-pentafluoropropane. A detailed synthesis is set forth below.

Sources & evidence

ORD record
ord-c48c9129cff54a50b689792847c3f3f6
Source dataset
uspto-grants-1994_02
Patent number
US05288819

Linked notes

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